Compte-rendu de l’ELC 2019

La NSFA encourage les chercheurs issus de laboratoires de recherche français à participer au congrès de l’European Lipoprotein Club (ELC). En 2019, la NSFA a accordé une aide financière de 400€ à une sélection de communications acceptées par le comité scientifique de l’ELC et présentées au congrès de la NSFA 2019. Cette année, nous étions 12 français à participer à ce meeting, nous propulsant au deuxième rang derrière les Pays-Bas (cocorico !!!), avec 8 subventions de la NSFA de 400 euros. Notre contingent a pu ainsi proposer 5 communications orales et présenter 6 posters.

Nous vous proposons ici quelques témoignages vidéos du congrès, ainsi que quelques photos illustrant le déroulement du programme proposé.


14:00 – 14:10      Welcome by Patrick Rensen (Leiden, The Netherlands)

Session VESSEL WALL (Chairperson: Nicola Ferri)

14:10 – 14:50      Invited speaker: Kees Hovingh (Amsterdam, NL): Genes: guidance in lipid-targeted therapy

14:50 – 15:10      Fabrizia Bonacina (Italy): Engineered regulatory T cell Adoptive Therapy as a novel tool for the treatment of atherosclerosis

15:10 – 15:30      Biaci Papotti (Italy): The anti-atherogenic role of sphingosine-1-phosphate (S1P) and its receptor S1P3 in the reverse cholesterol transport

15:30 – 15:50      Sara Oppi (Switzerland): The nuclear receptor corepressor 1 blocks CD36-mediated foam cell formation in atherogenesis

15:50-16:10        Maria Giovanna Lupo (Italy): PCSK9 induces smooth muscle cell-mediated calcification: in vitro and in vivo evidences

Session BRAIN & BUGS (Chairperson: Ruth Frikke-Schmidt)

16:40 – 17:00      Monique Mulder (The Netherlands): Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model

17:00 – 17:20      Emily Button (Canada): High-density lipoprotein deficiency in transgenic Alzheimer’s disease mice increases global and vascular specific amyloid pathology and neuroinflammation

17:20 – 17:40      Liv Nordestgaard (Denmark): Genetic inhibition of CETP and risk of ischemic heart disease, cardiovascular mortality, age-related macular degeneration, and dementia

17:40 – 18:00      Lisanne Blauw (The Netherlands): The biological function of CETP: modulation of HDL to resolve infections

18:00 – 18:20      Bart Staels (France): Hepatic PPARα is critical in the metabolic adaptation to sepsis (photo ci-dessous)

20:00 – 21:00      KEYNOTE LECTURE (Chairperson: Patrick Rensen)

Ira Tabas (New York, USA): Inflammation resolution and efferocytosis in atherosclerosis


Session LIPOPROTEINS (Chairperson: Katariina Öörni)

08:30 – 08:50      Pauli Ohukainen (Finland): Multivariate lipoprotein phenotyping supports the culprit role of apolipoprotein B in coronary heart disease

08:50 – 09:10      Cedric Le May (France): Pharmacological inhibition of circulating PCSK9 but not intestinal deficiency reduces post-prandial lipemia in mice

09:10 – 09:30      Maija Ruuth (Finland): Dietary saturated fats increase and plant stanol esters decrease LDL aggregation

09:30 – 09:50      Simon Pfisterer (Finland): Heterogeneity of LDL Uptake Responses in Individual Hypercholesterolemia Patients

09:50 – 10:10      Kristian Kolby Kristensen (Denmark): A disordered acidic domain in GPIHBP1 harboring a sulphated tyrosine regulates lipoprotein lipase

10:10 – 10:30      Vesa Olkkonen (Finland): The impacts of ANGPTL3 deficiency on serum lipoprotein measures and lipidome – comparison with omics data from ANGPTL3 silenced hepatocytes

Session LIPID & DROPLETS (Chairperson: Dagmar Kratky)

11:00 – 11:40      Invited speaker: Rosalind Coleman (Chapel Hill, USA): Cell organization and lipid metabolism

11:40 – 12:00      Sander Kersten (The Netherlands): Hypoxia-induced lipid droplet-associated (HILPDA) increases lipid accumulation in macrophages and hepatocytes via ATGL-dependent and -independent mechanisms

12:00 – 12:20      Melanie Korbelius (Austria): Contribution of neutral lipolysis on the catabolism of cytosolic lipid droplets in the small intestine

12:20 – 12:40      Benedikt Kien (Austria): Establishment of a model to investigate the impact of Perilipin 5 mediated peridroplet mitochondria formation

12:40 – 13:00      Suzanne van Wouw (The Netherlands): The role of the LXR-EEPD1 axis in cholesterol metabolism

14:00 – 15:30      Networking (photos ci-dessous)

19:30 – late      Wine and Poster Science (photos ci-dessous)


Session FATTY LIVER (Chairpersons: Kevin Jon Williams and Christina Christoffersen)

08:30 – 09:10      Invited speaker: Adil Madinoglu (Stockholm, Sweden): Use of systems biology in the treatment of NAFLD

09:10 – 09:30      Menno Hoekstra (The Netherlands): Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in ApoE knockout mice

09:30 – 09:50      Jan Kovar (Czech Republic): The acute response of hepatic fat content to high-fat load is more pronounced in subjects with non-alcoholic fatty liver disease than in control subjects

09:50 – 10:10      Alexandre Motte (France) : Postprandial changes in circulating lipoprotein-associated microRNAs distribution (photo)

10:40 – 11:00      Noam Zelcer (The Netherlands): A mammalian haploid genetic screen identifies the ERAD-associated E3 ubiquitin ligase MARCH6 as a novel determinant of hepatic fatty acid and lipoprotein metabolism

11:00 – 11:20      Joel Hass (France): The role of apolipoprotein F in the control of plasma and hepatic lipid metabolism (photo)

11:20 – 11:40      Wieneke Dijk (France): Identification of novel regulators of cholesterol metabolism by using a mass-spectrometry-based approach (photo)

11:40 – 12:00      Lorenzo Da Dalt (Italy): Tissue selective PCSK9-KO mice present altered glucose metabolism, pancreatic function and insulin release

13:00 15:00      Networking

Session BILE ACIDS (Chairperson: Mathilde Varret)

15:00 – 15:20      Ioannis Evangelakos (Germany): The role of the alternative pathway-derived bile acids in NAFLD progression

15:20 – 15:40      Jan Freark de Boer (The Netherlands): A human-like composition of the circulating bile acid pool impacts on plasma LDL-cholesterol in mice

15:40 – 16:00      Mats Rudling (Sweden): Mice devoid of murine bile acids display a human-like phenotype

16:00 – 16:20      Christian Wolfrum (Switzerland): Atypical bile acid signalling regulating adipocyte formation

16:20 – 16:40      Yanan Wang (The Netherlands): Δ24-Dehydrocholesterol reductase (DHCR24): a novel target for the treatment of NASH

16:40 – 17:00      ELC status and general discussion

19:00 – late      Party and Young Investigator Awards (photos ci-dessous)